IMMUNE CHECKPOINT INHIBITORS AS THE SECOND-LINE TREATMENT FOR ADVANCED ESOPHAGEAL SQUAMOUS CELL CARCINOMA: A COST-EFFECTIVENESS ANALYSIS BASED ON NETWORK META-ANALYSIS

Abstract Background Immune checkpoint inhibitors (ICIs) have demonstrated superior clinical efficacy in prolonging overall survival (OS) as the second-line treatment for advanced or metastatic esophageal squamous cell carcinoma (ESCC), and were recommended by the guidelines.However, it remains uncertain which ICI is the most cost-effective.This stu

Beckwith-Wiedemann syndrome (BWS) is a fetal overgrowth and human imprinting disorder resulting from the deregulation of a number of genes, including IGF2 and CDKN1C, in the imprinted gene cluster on chromosome 11p15.5.Most cases are sporadic and result from epimutations at either of the two 11p15.5 imprinting Body Gift Sets centres (IC1 and IC2).H

Bus-bridging evacuation services can significantly enhance metro resilience during Toddler Clothing operational disruptions.A resilience-based optimization model was proposed to generate a bus bridging and dispatching plan.The objective of the model is to maximize the resilience index of evacuated passengers while meeting pre-established restrictio

The main problem that is often found in the failure of microalgae production is poor water quality during the maintenance period.One of the causes of deteriorating water quality is the lack of Health oxygen which endangers microalgae which can inhibit cell growth so that it can reduce its productivity.On this basis, efforts are needed to refresh th

Myeloid Sarcoma Body Gift Sets (MS) is a rare malignancy that can present as an isolated disease or more frequently in association with or following acute myeloid leukemia or other myeloid neoplasms and rarely following myelofibrosis.Since molecular pathogenesis and prognostic factors of MS are not well understood, its prognosis remains poor even i